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As a result of DSBs, H2AX becomes phosphorylated at serine-139 (p Ser139). Anti-gamma H2A.X (phospho S139) antibody [EP854 (2)Y] (ab81299) Research with confidence – consistent and reproducible results with every batch. Long-term and scalable supply – powered by recombinant technology for fast production. Success from the first experiment – confirmed specificity through extensive validation. Gamma H2AX (gammaH2AX) is the phosphorylated version of histone H2AX and is a marker for double-stranded breaks (DSBs) caused by DNA damage (1-4).
H2A.X, H2A/X, H2AX, H2AX histone, histone H2A.x, histone H2AX. Immunogen. Surrounding serine 140. Protein Names.
Gamma H2AX (γH2AX) is the phosphorylated version of histone H2AX and is a marker for double-stranded breaks (DSBs) caused by DNA damage.
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Gamma H2AX is the phosphorylated form of H2AX that results in response to DNA damage. A gamma-H2AX kit and antibody allows the assessment of DNA damage and DNA repair for ELISA based assays, immunohistochemistry or flow cytometry. In the detection of genomic damage, gamma-H2AX is especially important in research involving cancer treatment and therapy, and environmental biomonitoring. Exclusively from The Antibody Resource, you can buy this Superstarter kit, which is a collection of trial sizes of these Superstar phospho-Histone H2A.x antibodies (highly rated and independently tested by us), to test using the specific experimental conditions which your research dictates, so that you can identify which will be the most appropriate for your research project.
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gamma H2AX Antibodies. Gamma H2AX (γH2AX) is the phosphorylated version of histone H2AX and is a marker for double-stranded breaks (DSBs) caused by DNA damage. As a result of DSBs, H2AX becomes phosphorylated at serine-139 (p Ser139). H2AX is a variant of histone H2A, one of the histone core molecules forming the nucleosome, and has a theoretical molecular weight of 15 kDa. Anti-gamma H2A.X (phospho S139) antibody [EP854 (2)Y] (ab81299) Research with confidence – consistent and reproducible results with every batch.
Histone H2AX: Products. Histone H2AX is one of a number of core histone proteins. In the cellular response to genotoxic insults, ATM and related protein kinases phosphorylate the carboxyl-terminal tail of the H2AX protein (gamma-H2AX).
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Detection: Red fluorescent Anti-rabbit IgG-DyLight® 594 conjugated used at a dilution of 1:100. gamma-H2AX Antibody, A300-081A. Rabbit anti-gamma-H2AX Antibody, Affinity Purified. Reactivity Human, Mouse. Applications WB, IHC, ICC-IF. Host Rabbit.
Bethyl is now a part of Fortis Life Sciences. Phospho-H2AX or γ-H2AX- is a marker of DNA double-stranded breaks and can therefore be used to monitor DNA repair after, for example, irradiation. In addition, positive staining for phospho-H2AX may indicate genomic instability and telomere dysfunction in tumour cells and tissues. induce its function. Phosphorylated H2AX (also termed, gamma-H2AX) functions to recruit and localize DNA repair proteins or cell cycle checkpoint factors to the DNA-damaged sites. In this way, phosphorylated H2AX promotes DNA repair and maintains genomic stability and thus helps prevent oncogenic transformations.
Histone H2AX, Histone H2A.X, H2AX_HUMAN. UniProt Code History. P16104, Q4ZGJ7, Q6IAS5. Gene Synonyms. H2AX, H2a.x, H2afx, H2A/X. 2021-02-25 · p-Histone H2A.X Antibody (Ser 139) is a mouse monoclonal IgG 1, cited in 38 publications, provided at 100 µg/ml; raised against a recombinant protein corresponding to the Ser 139 phosphorylated region of Histone H2A.X of human origin Monoclonal Antibody for studying H2AX (Ser139) phosphate in the Chromatin Regulation / Epigenetics research area.
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Anti-gamma H2AX Rabbit polyclonal antibody unconjugated VWR
Anti-Gamma H2AX (phospho-Ser139) antibody, Rabbit monoclonal (H2AX Ser139 p ); HEK 293 cells, monoclonal RM224, purified immunoglobulin; Suitable for immunocytochemistry; Histone H2AX (H2A histone family member X), a histone variant present in almost all eukaryotes, is coded by H2AFX gene; Evaluate Phosphorylated H2AX (gamma-H2AX) is essential to the efficient recognition and (or) repair of DNA double strand breaks (DSBs), and many molecules, often thousands, of H2AX become rapidly phosphorylated at the site of each nascent DSB. An antibody to gamma-H2AX reveals that this highly amplified process generates nuclear foci. PTM: Phosphorylated on Ser-140 (to form gamma-H2AFX) in response to DNA double strand breaks (DSBs) generated by exogenous genotoxic agents and by stalled replication forks, and may also occur during meiotic recombination events and immunoglobulin class switching in lymphocytes. Phosphorylation can extend up to several thousand nucleosomes from the actual site of the DSB and may mark the surrounding chromatin for recruitment of proteins required for DNA damage signaling and repair. By tagging gamma-H2AX histones with a fluorescent antibody, Dr. Bonner showed that exposing cells to ionizing radiation caused hundreds of H2AX histones near the site of a double-strand break to become phosphorylated within minutes, creating a rapid and highly amplified response akin to a cellular fire alarm.
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Exp Cell Res 300, 320–334 (2004). CAS Article 2017-02-03 · The combined γ-H2AX/H2AX ELISA is performed by coating different wells of the same plate (or two different plates) with 2 different capture antibodies, each specific for a different part of H2AX: an anti-H2A antibody able to bind all histone H2A types, including H2AX, and γ-H2AX antibody able to bind only the phosphorylated form of H2AX (serine 139). Phosphorylated on Ser-140 (to form gamma-H2AX or H2AX139ph) in response to DNA double strand breaks (DSBs) generated by exogenous genotoxic agents and by stalled replication forks, and may also occur during meiotic recombination events and immunoglobulin class switching in lymphocytes. Phosphorylation can extend up to several (NB100-79967) gamma H2AX [p Ser139] Antibody (EP854(2)Y) This product has been discontinued by Novus Biologicals, but remains here on CiteAb for record purposes. Antibody info 4.
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Antikroppstyp, Primary. Klonalitet, Polyclonal. Denna behandlingär parallellt med kronisk exponering för γ-strålning vid en Gamma-H2AX nivå ökar drastiskt tidigt efter utmanande bestrålning följt av en DNA double-strand breaks with gamma-H2AX antibody.
Invitrogen Anti-Phospho-gamma-H2AX (Ser139) Recombinant Monoclonal (RM224), Catalog # MA5-33062. Tested in Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (ELISA) and Luminex (LUM) applications. This antibody reacts with All, Human, Mouse, Rat samples. Supplied as 100 µg purified antibody (1 mg/mL).